7-苄基-2,6-二氯-7h-嘌呤合成路线 （共 13 条）
反应条件
1: 71 percent / aq. NaOH / acetonitrile / Heating 2: 65 percent / H2; KOH / 5 percent Pd/C / ethanol / 15 h / 760 Torr View Scheme
参考文献
Kochergin; Persanova; Aleksandrova
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 4 p. 455 - 458
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in ethanol; water Catalytic hydrogenation;
参考文献
Kochergin; Yakovleva; Persanova; Aleksandrova
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 6 p. 327 - 330
反应条件
1: 84 percent / KOH / acetonitrile / 3 h / Heating 2: 69 percent / H2; KOH / 5 percent Pd/C / ethanol / 15 h / 760 Torr View Scheme
参考文献
Kochergin; Persanova; Aleksandrova
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 4 p. 455 - 458
反应条件
potassium carbonate in acetonitrile
参考文献
Dalby, Christine; Bleasdale, Christine; Clegg, William; Elsegood, Mark R. J.; Golding, Bernard T.; Griffin, Roger J.
Angewandte Chemie, 1993 , vol. 105, # 12 p. 1822 - 1823
反应条件
1: 2,6-dichloro-purine With potassium carbonate in DMF (N,N-dimethyl-formamide)
0.333333 h;
2: benzyl chloride in DMF (N,N-dimethyl-formamide)
24 h;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1595882 A1, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
in dimethyl sulfoxide
参考文献
Pfizer Inc.
Patent: US5583137 A1, 1996 ;
反应条件
aluminum oxide
T=82 - 85°C; 6 h;
参考文献
Tumma, Harikrishna; Nagaraju; Reddy, K. Vijayakumar
Synthetic Communications, 2010 , vol. 40, # 12 p. 1856 - 1866
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
10 h; Ambient temperature;
参考文献
Toyota; Katagiri; Kaneko
Synthetic Communications, 1993 , vol. 23, # 9 p. 1295 - 1305
反应条件
phosphorus pentachloride; trichlorophosphate
T=18 - 20°C; 16 h;
参考文献
Kochergin, P. M.; Persanova, L. V.; Aleksandrova, E. V.; Gutorov, L. A.; Korsunskii, V. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995 , vol. 31, # 3 p. 337 - 339
Khimiya Geterotsiklicheskikh Soedinenii, 1995 , # 3 p. 388 - 390
反应条件
1: 85 percent
2: POCl3, PCl5 / 16 h / 18 - 20 °C
View Scheme
参考文献
Kochergin, P. M.; Persanova, L. V.; Aleksandrova, E. V.; Gutorov, L. A.; Korsunskii, V. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995 , vol. 31, # 3 p. 337 - 339
Khimiya Geterotsiklicheskikh Soedinenii, 1995 , # 3 p. 388 - 390
