4-(氰基甲基)-1H-咪唑-5-羧酸甲酯合成路线 (共 2 条)
反应条件
sodium hydride
1.) CH3CN, RT, 30 min, 2.) CH3CN, 3 h; Multistep reaction. Yields of byproduct given;
参考文献
Revankar, Ganapathi R.; Gupta, Pranab K.; Adams, Alexander D.; Dalley, N. Kent; McKernan, Patricia A.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1389 - 1396
反应条件
ammonium sulfate; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane
1.) reflux, 4 h, 2.) acetonitrile, dichloroethane, RT, 18 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Mian; Khwaja
Journal of medicinal chemistry, 1983 , vol. 26, # 2 p. 286 - 291