2-甲氧基-4-氯苯甲酰氯合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C; 72 h;
参考文献
Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz
Patent: US2005/209274 A1, 2005 ;
Location in patent: Page/Page column 21 ;
US 20050209274 A1
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 3 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 20 ;
US 20120277224 A1
反应条件
thionyl chloride in pyridine; water
参考文献
Boehringer Ingelheim Gesellschaft mit beschrankter Haftung
Patent: US4299834 A1, 1981 ;
反应条件
1: 81 percent / aluminium chloride / 1 h / Heating
2: 25 percent / potassium hydroxide / dimethylsulfoxide / 21 h / 40 °C
View Scheme
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.
Tetrahedron, 2006 , vol. 62, # 4 p. 737 - 745
反应条件
1: Py
2: aq. HCl / 2.5 h / Heating
View Scheme
参考文献
Dunwell,D.W. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58
