4-氨基-3-异丁基嘧啶-2,6-二酮合成路线 （共 4 条）
反应条件
sodium hydroxide; acetic anhydride 1.) from 75 deg C to 80 deg C, 2 h, 2.) RT; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 4 p. 487 - 492
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 4 p. 1397 - 1401
反应条件
sodium hydroxide; ethanol
参考文献
Papesch; Schroeder
Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887
反应条件
1: 1.) 20percent NaOH / 1.) EtOH, 50 deg C, 2.) EtOH, reflux, 2 h
2: 79 percent / NaNO2, 42percent AcOH / H2O / 0.17 h / 60 °C
3: 60 percent / H2 / PtO2 / methanol / 0.5 h / 2068.6 Torr
4: 64 percent / 1 h / Heating
5: 87 percent / 10percent NaOH / 0.33 h / Heating
View Scheme
参考文献
Daly, J.W.; Padgett, W.; Shamim, M.T.; Butts-Lamb, P.; Waters, J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 487 - 492
