1.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 2.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 2.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 3.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 4.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 5.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 5.2: CH2Cl2 / 3 h / -78 - 20 °C 6.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 7.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 8.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: 95 percent / H2SO4 / benzene / 18 h / Heating 2.1: α-chymotrypsin; NaOH / aq. phosphate buffer / 90 h / 20 °C / pH 7.5 - 7.8 3.1: 99 percent / B(OMe)3; BH3*DMS / tetrahydrofuran / 42 h / 20 °C 4.1: 86 percent / imidasole / dimethylformamide / 18 h / 20 °C 5.1: 96 percent / DIBAL-H / toluene; heptane / 2 h / -78 °C 6.1: sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 6.2: 91 percent / Bu4NI / dimethylformamide; various solvent(s) / 18 h / 20 °C 7.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C 8.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 9.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 10.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 11.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 12.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 13.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 14.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 14.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 15.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 16.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 17.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 17.2: CH2Cl2 / 3 h / -78 - 20 °C 18.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 19.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 20.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: 99 percent / B(OMe)3; BH3*DMS / tetrahydrofuran / 42 h / 20 °C 2.1: 86 percent / imidasole / dimethylformamide / 18 h / 20 °C 3.1: 96 percent / DIBAL-H / toluene; heptane / 2 h / -78 °C 4.1: sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 4.2: 91 percent / Bu4NI / dimethylformamide; various solvent(s) / 18 h / 20 °C 5.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C 6.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 7.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 8.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 9.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 10.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 11.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 12.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 12.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 13.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 14.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 15.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 15.2: CH2Cl2 / 3 h / -78 - 20 °C 16.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 17.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 18.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: 96 percent / DIBAL-H / toluene; heptane / 2 h / -78 °C 2.1: sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 2.2: 91 percent / Bu4NI / dimethylformamide; various solvent(s) / 18 h / 20 °C 3.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C 4.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 5.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 6.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 7.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 8.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 9.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 10.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 10.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 11.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 12.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 13.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 13.2: CH2Cl2 / 3 h / -78 - 20 °C 14.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 15.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 16.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: 86 percent / imidasole / dimethylformamide / 18 h / 20 °C 2.1: 96 percent / DIBAL-H / toluene; heptane / 2 h / -78 °C 3.1: sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 3.2: 91 percent / Bu4NI / dimethylformamide; various solvent(s) / 18 h / 20 °C 4.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C 5.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 6.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 7.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 8.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 9.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 10.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 11.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 11.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 12.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 13.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 14.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 14.2: CH2Cl2 / 3 h / -78 - 20 °C 15.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 16.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 17.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 2.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 3.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 4.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 5.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 6.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 7.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 7.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 8.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 9.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 10.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 10.2: CH2Cl2 / 3 h / -78 - 20 °C 11.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 12.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 13.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C 2.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 3.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 4.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 5.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 6.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 7.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 8.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 8.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 9.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 10.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 11.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 11.2: CH2Cl2 / 3 h / -78 - 20 °C 12.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 13.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 14.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 1.2: 91 percent / Bu4NI / dimethylformamide; various solvent(s) / 18 h / 20 °C 2.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C 3.1: 98 percent / 4-dimethylaminopyridine; triethylamine / CH2Cl2 / 18 h / 20 °C 4.1: 95 percent / dimethylsulfoxide / 5 h / 85 °C 5.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 4 h / -78 °C 6.1: 100 percent / NaBH4 / methanol / 0.75 h / 0 - 20 °C 7.1: 77 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C 8.1: 95 percent / Mo7O24(NH4)6*4H2O; H2O2 / ethanol; H2O / 18 h / 20 °C 9.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h 9.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C 10.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2O; CH2Cl2 / 2 h / 0 °C 11.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.92 h / -78 °C 12.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 12.2: CH2Cl2 / 3 h / -78 - 20 °C 13.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 14.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 15.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: diethyl ether / 2 h / -78 °C 2.1: 34 mg / Dess-Martin periodinane / CH2Cl2 / 3 h / 0 °C 3.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 3.2: CH2Cl2 / 3 h / -78 - 20 °C 4.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 5.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 6.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme

1.1: dibutylboron triflate; diisopropylethylamine / CH2Cl2 / 0.5 h / -78 °C 1.2: CH2Cl2 / 3 h / -78 - 20 °C 2.1: 12 mg / pyridine; chromium trioxide / CH2Cl2 / 0.33 h / 20 °C 3.1: 85 percent / HF / H2O; acetonitrile / 3 h / 20 °C 4.1: LiOH / H2O; 1,2-dimethoxy-ethane / 7 h / 80 °C View Scheme