6-甲基-2,2′-二吡啶合成路线 （共 5 条）
反应条件
1: diethyl ether 2: KMnO4 / acetone View Scheme
参考文献
Pijper; Van der Goot; Timmerman; Nauta Th.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 399 - 404
反应条件
1: 1) LDA / 1) THF, -10 deg C, 1h, 2) THF, -10 deg C 2: 70 percent / pyridine / 20 h / Heating 3: 95 percent / H2NNH2*H2O / ethanol / 20 h / Ambient temperature 4: 90 percent / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Graf
Synthesis, 1992 , # 6 p. 519 - 521
反应条件
selenium(IV) oxide in 1,4-dioxane
30 h; Reflux;
参考文献
Mundinger, Stephan; Jakob, Uwe; Bichovski, Plamen; Bannwarth, Willi
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 8968 - 8979,12
反应条件
1: 6-mbipy With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
Bromination; 8 h; Heating;
2: sodium acetate in N,N-dimethyl-formamide
T=100°C; Substitution; 4.5 h; Further stages.;
参考文献
Nakatani, Kazuhiko; Hagihara, Shinya; Sando, Shinsuke; Miyazaki, Hiroshi; Tanabe, Kazuhito; Saito, Isao
Journal of the American Chemical Society, 2000 , vol. 122, # 26 p. 6309 - 6310
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
Heating;
参考文献
Uenishi, Jun'ichi; Tanaka, Takakazu; Nishiwaki, Kenji; Wakabayashi, Shoji; Oae, Shigeru; Tsukube, Hiroshi
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4382 - 4388
