(2R)-2-(3-苯甲酰基苯基)丙酸合成路线 （共 22 条）
反应条件
1.1: rink amide linker modified polystyrene grafted crowns; piperidine; benzotriazolyloxy-tris(dimethylamino)phosphonium(1+) PF6(1-) / diisopropylethylamine / dimethylformamide / 12 h / 20 °C 1.2: triethylamine / tetrahydrofuran / 12 h / 0 °C 1.3: 104 mg / trifluoroacetic acid / CH2Cl2 / 0.67 h 2.1: LiOH / tetrahydrofuran; H2O / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5859 - 5865
反应条件
1: With (S)-(3-OH-4,4-di-Me-2-oxopyrrolidin-1-yl)CH2COOH on resin; triethylamine in tetrahydrofuran T=0°C; 2: With lithium hydroxide in tetrahydrofuran; water T=20°C; 4 h; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5859 - 5865
反应条件
novozyme 435 in water; acetonitrile T=45°C; 45 h;
参考文献
Monti, Sandra; Manoli, Francesco; Sortino, Salvatore; Morrone, Raffaele; Nicolosi, Giovanni
Physical Chemistry Chemical Physics, 2005 , vol. 7, # 23 p. 4002 - 4008
反应条件
lithium hydroxide in tetrahydrofuran; water T=20°C; 1 h;
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5859 - 5865
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 2 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
sodium hydroxide; potassium permanganate in water 6 h; Ambient temperature; Yield given;
参考文献
Comisso, Giovanni; Mihalic, Mladen; Kajfez, Franjo; Sunjic, Vitomir; Snatzke, Guenther
Gazzetta Chimica Italiana, 1980 , vol. 110, # 2/3 p. 123 - 128
反应条件
1: 93 percent / 3percent KOH/H2O / tetrahydrofuran / 24 h / Ambient temperature 2: H2, <RhCl-1,5-hexadiene>2/(-)-DIOP/NEt3 / ethanol; benzene / 11172 - 77140 Torr / different solvents, without NEt3, with KOH; other object: optical yield View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 110, # 2/3 p. 123 - 128
反应条件
Novozym 435; water in tert-butyl methyl ether T=45°C; Kinetics; SolventConcentration;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 14-15 p. 2333 - 2341
反应条件
Novozym 435; water in tert-butyl methyl ether T=45°C; Kinetics; SolventConcentration; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 14-15 p. 2333 - 2341
反应条件
Mesorhizobium sp. BNC1 arylmalonate decarboxylase Enzymatic reaction; enantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 69, # 3-4 p. 140 - 146
