1-苄基-4-(4-氯苯基)-4-哌啶醇合成路线 （共 8 条）
反应条件
N-benzyl-trimethylammonium hydroxide T=20°C; Neat (no solvent);
参考文献
Meshram; Reddy, B. Chennakesava; Goud, P. Ramesh
Synthetic Communications, 2009 , vol. 39, # 13 p. 2297 - 2303
反应条件
potassium carbonate in methanol; dichloromethane; N,N-dimethyl-formamide
参考文献
Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.
Patent: US2005/70549 A1, 2005 ;
反应条件
in tetrahydrofuran T=0°C;
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
magnesium 1.) ether, 2.) reflux, 2 h; room temp., overnight; Multistep reaction;
参考文献
Journal of Chemical and Engineering Data, , vol. 25, # 2 p. 176 - 183
反应条件
1: 70 percent / dimethylformamide / 70 °C 2: 76 percent / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 495 - 500
反应条件
1: 70 percent / dimethylformamide / 70 °C 2: 76 percent / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 495 - 500
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal 1.) H2O, 2.) H2O, reflux; Multistep reaction;
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
反应条件
1.1: 94 percent / P2O5 / toluene / Heating 2.1: 91 percent / H2; (Ph3P)3RhCl / toluene / 70 °C 3.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 2 h / Heating 3.2: 82 percent / MeOH / Heating View Scheme
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
