1-苄基-4-(3-三氟甲基)苯基-4-哌啶醇合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
US2005/176722 A1, ;
Page/Page column 10 ;
反应条件
1: 1-bromo-3-trifluoromethyl-benzene With iodine; magnesium in tetrahydrofuran Grignard reaction; Inert atmosphereReflux; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran T=20°C; Grignard reaction; 3 h; Inert atmosphereCooling with ice;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564
反应条件
1: methanesulfonic acid / toluene / 4 h / Reflux 2: hydrogenchloride / diethyl ether; ethyl acetate 3: palladium 10 on activated carbon; hydrogen / ethanol / 60 h View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
