4,4-二甲基-7-硝基-1,2,3,4-四氢喹啉合成路线 （共 8 条）
反应条件
2: Pd-C / methanol View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
KNO3 in sulfuric acid
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
Title/Abstract Full Text Show Details
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1: With sulfuric acid
T=0°C; 0.5 h;
2: With sulfuric acid; nitric acid
T=0 - 15°C; 2.33333 h;
参考文献
AMGEN INC.
Patent: WO2007/48070 A2, 2007 ;
Location in patent: Page/Page column 124 ;
反应条件
1: AlCl3 / CH2Cl2 / Heating
2: borane*dimethylsulfide complex / tetrahydrofuran / Heating
3: 90 percent HNO3, H2SO4 / 0 °C
View Scheme
参考文献
Higuchi, Robert I.; Edwards, James P.; Caferro, Thomas R.; Ringgenberg, Josef D.; Kong, James W.; Hamann, Lawrence G.; Arienti, Kristen L.; Marschke, Keith B.; Davis, Robert L.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1335 - 1340
反应条件
1: thionyl chloride; aniline / dichloromethane; triethylamine
2: AlCl3 / benzene
3: NaOH; LiAlH4 / tetrahydrofuran; water
4: KNO3 / sulfuric acid
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: borane*dimethylsulfide complex / tetrahydrofuran / Heating
2: 90 percent HNO3, H2SO4 / 0 °C
View Scheme
参考文献
Higuchi, Robert I.; Edwards, James P.; Caferro, Thomas R.; Ringgenberg, Josef D.; Kong, James W.; Hamann, Lawrence G.; Arienti, Kristen L.; Marschke, Keith B.; Davis, Robert L.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1335 - 1340
反应条件
1: Et3N / CH2Cl2
2: AlCl3 / CH2Cl2 / Heating
3: borane*dimethylsulfide complex / tetrahydrofuran / Heating
4: 90 percent HNO3, H2SO4 / 0 °C
View Scheme
参考文献
Higuchi, Robert I.; Edwards, James P.; Caferro, Thomas R.; Ringgenberg, Josef D.; Kong, James W.; Hamann, Lawrence G.; Arienti, Kristen L.; Marschke, Keith B.; Davis, Robert L.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1335 - 1340
反应条件
1: Et3N / CH2Cl2
2: AlCl3 / CH2Cl2 / Heating
3: borane*dimethylsulfide complex / tetrahydrofuran / Heating
4: 90 percent HNO3, H2SO4 / 0 °C
View Scheme
参考文献
Higuchi, Robert I.; Edwards, James P.; Caferro, Thomas R.; Ringgenberg, Josef D.; Kong, James W.; Hamann, Lawrence G.; Arienti, Kristen L.; Marschke, Keith B.; Davis, Robert L.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1335 - 1340
