sodium hydroxide; potassium permanganate; water

1: diethyl ((methylsulfonyl)methyl)phosphonate With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: 3-(2,5-dioxo-pyrrolidin-1-yl)propionaldehyde in tetrahydrofuran; hexane T=-78 - 20°C;

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 45 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 40 percent / Lawesson's reagent / toluene / Heating View Scheme