5-羟基苯并呋喃-2-羧酸合成路线 （共 11 条）
反应条件
PS 4-(methylazoamino)phenoxymethyl resin in dichloromethane T=20°C; 2 h;
参考文献
SENOMYX, INC.; TACHDJIAN, Catherine; LI, Xiaodong; KARANEWSKY, Donald S.; FOTSING, Joseph; PATRON, Andrew; DARMOHUSODO, Vincent; SELCHAU, Victor; CHING, Brett
Patent: WO2011/159781 A2, 2011 ;
Location in patent: Page/Page column 67 ;
WO 2011/159781 A2
反应条件
thionyl chloride 24 h;
参考文献
Martin; Winkler
Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 100 - 110
反应条件
boron tribromide in dichloromethane
T=-78 - 20°C; 4 h;
参考文献
Cheng, Jie Fei; Nguyen, Bao Ngoc; Liu, Xuewei; Lopaschuk, Gary D.; Dyck, Jason R.
Patent: US2005/26969 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050026969 A1
反应条件
boron tribromide in dichloromethane
T=-40 - 20°C; 1 h;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2009/65131 A1, 2009 ;
Location in patent: Page/Page column 114 ;
WO 2009/065131 A1
反应条件
boron tribromide in dichloromethane
T=20°C; 1 h;
参考文献
Bailly, Fabrice; Maurin, Cedric; Teissier, Elisabeth; Vezin, Herve; Cotelle, Philippe
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5611 - 5618
反应条件
boron tribromide in dichloromethane
18 h;
参考文献
Martin; Winkler
Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 100 - 110
反应条件
1: 76 percent / NaOAc; Ac2O / 8 h / 100 °C
2: 40 percent / aq. HCl / 4 h / 100 °C
3: boron tribromide / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Bailly, Fabrice; Maurin, Cedric; Teissier, Elisabeth; Vezin, Herve; Cotelle, Philippe
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5611 - 5618
反应条件
1: 40 percent / aq. HCl / 4 h / 100 °C
2: boron tribromide / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Bailly, Fabrice; Maurin, Cedric; Teissier, Elisabeth; Vezin, Herve; Cotelle, Philippe
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5611 - 5618
反应条件
1: 43 percent / K2CO3 / dimethylformamide / 4 h, r.t.; 18 h, 80 deg C
2: 50 percent / BBr3 / CH2Cl2 / 18 h
View Scheme
参考文献
Martin; Winkler
Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 100 - 110
反应条件
bromine; potassium acetate in acetic acid
T=0 - 20°C; 2.5 h;
参考文献
Cheng, Jie Fei; Nguyen, Bao Ngoc; Liu, Xuewei; Lopaschuk, Gary D.; Dyck, Jason R.
Patent: US2005/26969 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050026969 A1
