DL-苯基丙氨酸甲酯盐酸盐合成路线 （共 39 条）
反应条件
1: potassium carbonate; (benzyl)-tri-(butyl)-ammonium chloride / toluene / 5 h / 70 °C 2: hydrogenchloride; water / 30 h / |Reflux 3: hydrogenchloride / water / 1 h / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 13 p. 2264 - 2271
反应条件
1: potassium carbonate; (benzyl)-tri-(butyl)-ammonium chloride / toluene / 5 h / 70 °C 2: hydrogenchloride; water / 30 h / |Reflux 3: hydrogenchloride / water / 1 h / |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 13 p. 2264 - 2271
反应条件
thionyl chloride; palladium on activated charcoal 1.) 6 h, RT; 2.) 10 h, reflux; Yield given. Multistep reaction;
参考文献
Gazzetta Chimica Italiana, , vol. 119, # 4 p. 215 - 216
反应条件
H2 in methanol Pd/C-catalyst, a stream of H2 for 20 min at room temp.; filtration, evapn. of solvent;
参考文献
Chemische Berichte, , vol. 121, p. 1021 - 1026
反应条件
ammonia in methanol 96 h; Ambient temperature;
参考文献
Yasukawa, Kazuyuki; Asano, Yasuhisa
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3327 - 3332
反应条件
1: 36 percent / H2SO4, NaOAc, NaNO2 / diethyl ether; H2O 2: 400 °C / 0 - 0.1 Torr View Scheme
参考文献
Aitken, R. Alan; Armstrong, Jill M.; Drysdale, Martin J.; Ross, Fiona C.; Ryan, Bruce M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1999 , # 5 p. 593 - 604
反应条件
1: pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 4 h / 20 °C 2: Rhizomucor miehei lipase / acetonitrile / 24 h / 30 °C / |Inert atmosphere; |Enzymatic reaction View Scheme
参考文献
Da Silva, Marcos Reinaldo; De Mattos, Marcos Carlos; De Oliveira, Maria Da Conceicao Ferreira; De Lemos, Telma Leda Gomes; Ricardo, Nagila Maria Pontes Silva; De Gonzalo, Gonzalo; Lavandera, Ivan; Gotor-Fernandez, Vicente; Gotor, Vicente
Tetrahedron, 2014 , vol. 70, # 13 p. 2264 - 2271
反应条件
T=30°C; 0.333333 h; enzyme alcalase from Bacillus licheniforms; pH 8.0; Yields of byproduct given;
参考文献
Chen, Shui-Tein; Wang, Kung-Tsung; Wong, Chi-Huey
Journal of the Chemical Society, Chemical Communications, 1986 , # 20 p. 1514 - 1516
反应条件
1: ammonia / methanol / 0 °C 2: PLP / aq. buffer / 6 h / 40 °C / pH 8.0 / |Enzymatic reaction View Scheme
参考文献
Yasukawa, Kazuyuki; Asano, Yasuhisa
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3327 - 3332
反应条件
1: 46.2 percent / Triethylamine / methanol / 36 h / Heating 2: 88.2 percent / Aq. NaOH / 0.5 h / 100 °C View Scheme
参考文献
New, J. S.; Yevich, J. P.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1355 - 1360
