DL-苯基丙氨酸甲酯盐酸盐合成路线 （共 39 条）
参考文献
G. D. Searle and Co.
Patent: US4017472 A1, 1977 ;
反应条件
Aspergillus niger lipase; sodium acetate buffer
参考文献
Janes, Lana E.; Kazlauskas, Romas J.
Tetrahedron Asymmetry, 1997 , vol. 8, # 22 p. 3719 - 3733
反应条件
T=30°C; 0.333333 h; enzyme alcalase from Bacillus licheniforms; pH 8.0; Yields of byproduct given;
参考文献
Chen, Shui-Tein; Wang, Kung-Tsung; Wong, Chi-Huey
Journal of the Chemical Society, Chemical Communications, 1986 , # 20 p. 1514 - 1516
反应条件
1: ammonia / methanol / 0 °C 2: PLP; cobalt(II) chloride / aq. buffer / 4 h / 40 °C / pH 7.0 / |Enzymatic reaction View Scheme
参考文献
Yasukawa, Kazuyuki; Asano, Yasuhisa
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3327 - 3332
反应条件
1: 36 percent / H2SO4, NaOAc, NaNO2 / diethyl ether; H2O
2: 400 °C / 0 - 0.1 Torr
View Scheme
参考文献
Aitken, R. Alan; Armstrong, Jill M.; Drysdale, Martin J.; Ross, Fiona C.; Ryan, Bruce M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1999 , # 5 p. 593 - 604
反应条件
1: 1.) 4,4-dimethylaminopyridine, Et3N, 2.) dicyclohexylcarbodiimide / 1.) CH2Cl2, 0 deg C, 5 min, 2.) CH2Cl2, a) from 0 deg C to RT, 2 h, b) RT, 16 h
2: HCl (gas) / dimethylformamide / 60 °C
View Scheme
参考文献
Akssira; Boumzebra; Kasmi; Dahdouh; Roumestant; Viallefont
Synthetic Communications, 1993 , vol. 23, # 16 p. 2265 - 2272
反应条件
T=30°C; 0.333333 h; enzyme alcalase from Bacillus licheniforms; pH 8.0; Yields of byproduct given;
参考文献
Chen, Shui-Tein; Wang, Kung-Tsung; Wong, Chi-Huey
Journal of the Chemical Society, Chemical Communications, 1986 , # 20 p. 1514 - 1516
反应条件
sodium carbonate in water
3 h; Ambient temperature;
参考文献
Versleijen; Sanders-Hovens; Vanhommerig; Vekemans; Meijer
Tetrahedron, 1993 , vol. 49, # 35 p. 7793 - 7802
反应条件
1: triethylamine; acetic acid
2: methanol; aqueous NaOH
View Scheme
参考文献
Botvinik,M.M. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, # 5 p. 1619 - 1622,1603 - 1605
