3-二苯基-4-基-3-氧-丙 酸 甲基 酯合成路线 （共 3 条）
反应条件
NaH in ethyl acetate; N,N-dimethyl-formamide
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: EP1109560 B1, 2003 ;
反应条件
1: potassium dimethylmalonate With triethylamine; magnesium chloride in acetonitrile
T=20°C; 4 h;
2: 1-(biphenyl-4-carbonyl)-1H-imidazole in acetonitrile
T=20°C;
参考文献
Kainuma, Masahiko; Makishima, Makoto; Hashimoto, Yuichi; Miyachi, Hiroyuki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2587 - 2600
反应条件
1.1: tetrahydrofuran / 20 °C
2.1: magnesium chloride; triethylamine / acetonitrile / 4 h / 20 °C
2.2: 11.3 g / acetonitrile / 20 °C
View Scheme
参考文献
Kainuma, Masahiko; Makishima, Makoto; Hashimoto, Yuichi; Miyachi, Hiroyuki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2587 - 2600
