(E)-11-十六碳烯-1-醇乙酸酯合成路线 （共 36 条）
反应条件
1: 70 percent / PBr3, pyridine / diethyl ether / 1) overnight, 2) reflux, 1 h
2: 52 percent / Li2CuCl4 / tetrahydrofuran / 4 h / -10 °C
3: 68 percent / acetic acid / 35 - 40 °C
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Vohra, Neelam; Sabharwal, Arun; Huq, M. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1069 - 1070
反应条件
1: 77 percent / LiAlH4 / diethyl ether / 1) r.t., overnight, 2) reflux, 6 h
2: 70 percent / PBr3, pyridine / diethyl ether / 1) overnight, 2) reflux, 1 h
3: 52 percent / Li2CuCl4 / tetrahydrofuran / 4 h / -10 °C
4: 68 percent / acetic acid / 35 - 40 °C
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Vohra, Neelam; Sabharwal, Arun; Huq, M. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1069 - 1070
反应条件
1: LiAlH4 / bis-(2-methoxy-ethyl) ether / 15 °C
2: acetic acid / 10 h / 50 °C
View Scheme
参考文献
Oprean, I.; Ciupe, Hilke; Gansca, Lucia; Hodosan, F.
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 2 p. 283 - 289
反应条件
1: 93 percent / tetrahydrofuran / 48 h
2: 1.) n-BuLi / 1.) THF, -78 to 0 deg C; 2.) -110 deg C to r.t., 2 h
3: 1.) 9-BBN; 2.) 3 M NaOH, 30 percent H2O2 / 1.) 2h, r.t., THF; 2.) reflux, 1.5 h
4: 90 percent / acetonitrile / 0.5 h / Ambient temperature
View Scheme
参考文献
Soderquist, John A.; Anderson, Charles L.
Tetrahedron Letters, 1988 , vol. 29, # 23 p. 2777 - 2778
反应条件
1: 1.) n-BuLi / 1.) THF, -78 to 0 deg C; 2.) -110 deg C to r.t., 2 h
2: 1.) 9-BBN; 2.) 3 M NaOH, 30 percent H2O2 / 1.) 2h, r.t., THF; 2.) reflux, 1.5 h
3: 90 percent / acetonitrile / 0.5 h / Ambient temperature
View Scheme
参考文献
Soderquist, John A.; Anderson, Charles L.
Tetrahedron Letters, 1988 , vol. 29, # 23 p. 2777 - 2778
反应条件
1: 1.) n-BuLi / 1.) THF, -78 to 0 deg C; 2.) -110 deg C to r.t., 2 h
2: 1.) 9-BBN; 2.) 3 M NaOH, 30 percent H2O2 / 1.) 2h, r.t., THF; 2.) reflux, 1.5 h
3: 90 percent / acetonitrile / 0.5 h / Ambient temperature
View Scheme
参考文献
Soderquist, John A.; Anderson, Charles L.
Tetrahedron Letters, 1988 , vol. 29, # 23 p. 2777 - 2778
反应条件
1: 1.) 9-BBN; 2.) 3 M NaOH, 30 percent H2O2 / 1.) 2h, r.t., THF; 2.) reflux, 1.5 h
2: 90 percent / acetonitrile / 0.5 h / Ambient temperature
View Scheme
参考文献
Soderquist, John A.; Anderson, Charles L.
Tetrahedron Letters, 1988 , vol. 29, # 23 p. 2777 - 2778
反应条件
in acetic acid
48 h; Ambient temperature;
参考文献
Pop, Lidia; Oprean, I.; Barabas, A.; Hodosan, F.
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 5/6 p. 867 - 878
反应条件
1: 90 percent / acetonitrile
2: 63 percent / DMSO, NaH / tetrahydrofuran / 0.5 h
3: pyridine
View Scheme
参考文献
Horiike; Tanouchi; Hirano
Agricultural and Biological Chemistry, 1980 , vol. 44, # 2 p. 257 - 261
反应条件
1: 63 percent / DMSO, NaH / tetrahydrofuran / 0.5 h
2: pyridine
View Scheme
参考文献
Horiike; Tanouchi; Hirano
Agricultural and Biological Chemistry, 1980 , vol. 44, # 2 p. 257 - 261
