3-(4-(三氟甲基)苯氧基)-N,N-二甲基-3-苯基丙-1-胺合成路线 （共 10 条）
反应条件
triethylamine in toluene T=80°C;
参考文献
EGIS GYOGYSZERGYAR Nilvanosan Muekoedoe; MEZEI, Tibor; KOVANYINE LAX, Gyoergyi; BARKOCZY, Jozsef; VOLK, Baklazs; PORCS-MAKKAY, Marta; LUKACS, Gyula; MOLNAR, Enikoe; KOCSIS, Laszlo Jozsefne; KRASZNAI, Gy]orgy; KOeHEGYI, Imre; BRODA, Judit
Patent: WO2010/10412 A2, 2010 ;
Location in patent: Page/Page column 35-36 ;
参考文献
Eli Lilly and Company
Patent: US4584404 A1, 1986 ;
US 4584404 A
反应条件
sodium hydroxide in methanol
参考文献
Conjuchem, Inc.
Patent: US6706892 B1, 2004 ;
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate
T=80°C; 24 h; Sealed tube;
参考文献
Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda Gronborg; Koldso, Heidi; Schiott, Birgit; Stromgaard, Kristian; Kristensen, Anders S.
Molecular Pharmacology, 2014 , vol. 85, # 5 p. 703 - 714
反应条件
1: N,N-dimethyl-3-phenyl-3-hydroxy-propanamine With methanesulfonyl chloride; triethylamine in acetonitrile
T=20°C; 3 h;
2: 4-(trifluoromethyl)phenol With potassium carbonate in acetonitrile
16 h; Heating;
参考文献
O'Brien, Peter; Phillips, David W.; Towers, Timothy D.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7333 - 7335
反应条件
1: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol With methanesulfonyl chloride; triethylamine in acetonitrile
T=20°C; 3 h;
2: 4-(trifluoromethyl)phenol With potassium carbonate in acetonitrile
65 h; Heating;
参考文献
O'Brien, Peter; Phillips, David W.; Towers, Timothy D.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7333 - 7335
反应条件
1.1: N-bromosuccinmide; dibenzoyl peroxide / chlorobenzene / 4 h / 85 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / |Inert atmosphere; |Sonication
2.2: 12 h / 20 °C / |Inert atmosphere
3.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / 24 h / 80 °C / |Sealed tube
View Scheme
参考文献
Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda Gronborg; Koldso, Heidi; Schiott, Birgit; Stromgaard, Kristian; Kristensen, Anders S.
Molecular Pharmacology, 2014 , vol. 85, # 5 p. 703 - 714
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / |Inert atmosphere; |Sonication
1.2: 12 h / 20 °C / |Inert atmosphere
2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / 24 h / 80 °C / |Sealed tube
View Scheme
参考文献
Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda Gronborg; Koldso, Heidi; Schiott, Birgit; Stromgaard, Kristian; Kristensen, Anders S.
Molecular Pharmacology, 2014 , vol. 85, # 5 p. 703 - 714
参考文献
Eli Lilly and Company
Patent: US4018895 A1, 1977 ;
反应条件
triethylamine in toluene
T=80°C;
参考文献
EGIS GYOGYSZERGYAR Nilvanosan Muekoedoe; MEZEI, Tibor; KOVANYINE LAX, Gyoergyi; BARKOCZY, Jozsef; VOLK, Baklazs; PORCS-MAKKAY, Marta; LUKACS, Gyula; MOLNAR, Enikoe; KOCSIS, Laszlo Jozsefne; KRASZNAI, Gy]orgy; KOeHEGYI, Imre; BRODA, Judit
Patent: WO2010/10412 A2, 2010 ;
Location in patent: Page/Page column 35-36 ;
