2-氧杂-3-氮杂双环[2,2,2]辛-5-烯盐酸盐合成路线 （共 3 条）
反应条件
1: (+/-)-2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride With [1,3]-dithiolane-2-carbaldehyde in isopropyl alcohol T=40°C; 30 h; 2: With hydrogenchloride in water 3: di-tert-butyl dicarbonate With sodium hydroxide in water Reactivity; TemperatureTimeReagent/catalyst;
参考文献
Galvani, Gilles; Calvet, Geraldine; Blanchard, Nicolas; Kouklovsky, Cyrille
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 6 p. 1063 - 1070
反应条件
1: With hydrogen; platinum(IV) oxide P=1500.15 Torr; 7 h; 2: With hydrogenchloride in 1,4-dioxane
参考文献
SANOFI-AVENTIS DEUTSCHLAND GMBH
Patent: WO2007/12422 A1, 2007 ;
Location in patent: Page/Page column 82-83 ;
WO 2007/012422 A1
反应条件
potassium carbonate in ethanol; water
1 h; Heating;
参考文献
Riddell,F.G. et al.
Tetrahedron, 1979 , vol. 35, p. 259 - 261
