4-氯-1(2H-)-异喹啉酮合成路线 （共 3 条）
反应条件
trichlorophosphate 4 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/51410 A1, 2005 ;
Location in patent: Page/Page column 93 ;
反应条件
chlorosulfonic acid T=100°C; 84 h;
参考文献
Fish, Paul V.; Barber, Christopher G.; Brown, David G.; Butt, Richard; Collis, Michael G.; Dickinson, Roger P.; Henry, Brian T.; Horne, Valerie A.; Huggins, John P.; King, Elizabeth; O'Gara, Margaret; McCleverty, Dawn; McIntosh, Fraser; Phillips, Christopher; Webster, Robert
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2341 - 2351
反应条件
1: 18.75 g / ClSO3H / 84 h / 100 °C 2: 20 g / POCl3 / acetonitrile / 15 h / Heating View Scheme
参考文献
Fish, Paul V.; Barber, Christopher G.; Brown, David G.; Butt, Richard; Collis, Michael G.; Dickinson, Roger P.; Henry, Brian T.; Horne, Valerie A.; Huggins, John P.; King, Elizabeth; O'Gara, Margaret; McCleverty, Dawn; McIntosh, Fraser; Phillips, Christopher; Webster, Robert
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2341 - 2351
