4-苯基-1(3)H-咪唑-2-甲醛合成路线 （共 2 条）
反应条件
1: With ammonium acetate in methanol; water
T=20°C; 16 h;
2: With hydrogenchloride in methanol; water
T=80°C; 0.5 h;
3: With sodium hydroxide in water
pH=9;
参考文献
H. LUNDBECK A/S; KEHLER, Jan; RITZEN, Andreas; LANGGAaRD, Morten; NIELSEN, Jacob; FARAH, Mohamed; LETH-PETERSEN, Sebastian; KILBURN, John Paul
Patent: WO2012/7006 A1, 2012 ;
Location in patent: Page/Page column 60 ;
WO 2012/007006 A1
反应条件
1: With trifluoroacetic acid in dichloromethane
T=20°C; 1 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong
Patent: WO2011/150156 A2, 2011 ;
Location in patent: Page/Page column 115 ;
WO 2011/150156 A2
