4-溴-3-甲氧基苯甲酸合成路线 （共 14 条）
反应条件
hydrogenchloride; lithium hydroxide in tetrahydrofuran; methanol
参考文献
Vergne, Fabrice; Ducrot, Pierre; Andrianjara, Charles; Bernardelli, Patrick; Lorthois, Edwige
Patent: US2003/45557 A1, 2003 ;
反应条件
1: With n-butyllithium; potassium tert-butylate in tetrahydrofuran T=-78 - -50°C; 2 h; 2: With 1,1-dibromo-tetrachloro-ethane in tetrahydrofuran T=-50°C; 0.5 h; 3: With hydrogenchloride T=20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Organic Letters, 2005 , vol. 7, # 12 p. 2445 - 2448
反应条件
trimethylsilyl bromide; phenylmethyltriethylammonium bromide; sodium nitrite in N,N-dimethyl-formamide T=0°C; 2 h;
参考文献
Mineno, Tomoko; Ueno, Tasuku; Urano, Yasuteru; Kojima, Hirotatsu; Nagano, Tetsuo
Organic Letters, 2006 , vol. 8, # 26 p. 5963 - 5966
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C 2.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 1 h / 20 °C 2.2: pH 4 / Cooling with ice View Scheme
参考文献
WO2011/64328 A1, ;
WO 2011/064328 A1
反应条件
1: dimethylformamide / Heating 2: (oxidation) View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2202 - 2204
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2202 - 2204
参考文献
Journal of the Chemical Society, , vol. 127, p. 880
反应条件
potassium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; MAIS, Franz-Josef
Patent: WO2014/9219 A1, 2014 ;
Location in patent: Page/Page column 73 ;
参考文献
Wakamoto Pharmaceutical Co., Ltd.
Patent: EP1820799 A1, 2007 ;
EP 1820799 A1
反应条件
borane in tetrahydrofuran; methanol
参考文献
Smithkline Beckman Corporation
Patent: US4707483 A1, 1987 ;
