5,6-二氢胸腺嘧啶脱氧核苷合成路线 （共 22 条）
反应条件
Rh/Al2O3; hydrogen in methanol; water
168 h;
参考文献
Heil, Korbinian; Kneuttinger, Andrea Christa; Schneider, Sabine; Lischke, Ulrike; Carell, Thomas
Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9651 - 9657
反应条件
1,4-dithio-DL-threitol; potassium chloride; (S)-adenosylmethionine in various solvent(s)
T=4°C; 12 h;
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1.1: 81 percent / TFA / CH2Cl2; H2O / 4 h / 0 °C
2.1: 91 percent / imidazole / dimethylformamide / 20 °C
3.1: 64 percent / iPrNEt / CH2Cl2 / 96 h / 20 °C
4.1: 20 percent / NBS; benzoyl peroxide / CCl4 / 1 h / 70 °C
5.1: LDA / tetrahydrofuran; toluene; hexane / 2 h / -78 °C
5.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
6.1: 13.0 mg / HF; pyridine / acetonitrile / 0.67 h / -30 °C
7.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
8.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
9.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
methanol; formic acid
T=5 - 20°C; Inert atmosphere; chemoselective reaction;
参考文献
Chandra, Tilak; Broderick, William E.; Broderick, Joan B.
Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 11-12 p. 1016 - 1029
反应条件
1.1: 64 percent / iPrNEt / CH2Cl2 / 96 h / 20 °C
2.1: 20 percent / NBS; benzoyl peroxide / CCl4 / 1 h / 70 °C
3.1: LDA / tetrahydrofuran; toluene; hexane / 2 h / -78 °C
3.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
4.1: 13.0 mg / HF; pyridine / acetonitrile / 0.67 h / -30 °C
5.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
6.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
7.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1.1: 20 percent / NBS; benzoyl peroxide / CCl4 / 1 h / 70 °C
2.1: LDA / tetrahydrofuran; toluene; hexane / 2 h / -78 °C
2.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
3.1: 13.0 mg / HF; pyridine / acetonitrile / 0.67 h / -30 °C
4.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
5.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
6.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1.1: LDA / tetrahydrofuran; toluene; hexane / 2 h / -78 °C
1.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
2.1: 13.0 mg / HF; pyridine / acetonitrile / 0.67 h / -30 °C
3.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
4.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
5.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
2: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
2: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
3: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1.1: 91 percent / imidazole / dimethylformamide / 20 °C
2.1: 64 percent / iPrNEt / CH2Cl2 / 96 h / 20 °C
3.1: 20 percent / NBS; benzoyl peroxide / CCl4 / 1 h / 70 °C
4.1: LDA / tetrahydrofuran; toluene; hexane / 2 h / -78 °C
4.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
5.1: 13.0 mg / HF; pyridine / acetonitrile / 0.67 h / -30 °C
6.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
7.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
8.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
