5,6-二氢胸腺嘧啶脱氧核苷合成路线 （共 22 条）
反应条件
1.1: 60 percent / NBS; benzoyl peroxide / CCl4 / 1 h / 70 °C
2.1: LDA / toluene; tetrahydrofuran; hexane / 2 h / -78 °C
2.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
3.1: 82.0 mg / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
4.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
5.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1.1: LDA / toluene; tetrahydrofuran; hexane / 2 h / -78 °C
1.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C
2.1: 82.0 mg / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
3.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C
4.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C
2: H2 / Rh/Al2O3 / H2O; methanol / 72 h / 20 °C
View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
反应条件
1: 74 percent / Dess-Martin periodinane / CH2Cl2 / 0 - 25 °C
2: 69 percent / NH4F / methanol
3: 1,4-cyclohexadiene, D2O / acetonitrile / Irradiation; different traping reagents; other solvents; presence O2
View Scheme
参考文献
Barvian; Greenberg
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 1916 - 1917
反应条件
1: 69 percent / NH4F / methanol
2: 1,4-cyclohexadiene, D2O / acetonitrile / Irradiation; different traping reagents; other solvents; presence O2
View Scheme
参考文献
Barvian; Greenberg
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 1916 - 1917
反应条件
1: s-BuLi / tetrahydrofuran
2: 74 percent / Dess-Martin periodinane / CH2Cl2 / 0 - 25 °C
3: 69 percent / NH4F / methanol
4: 1,4-cyclohexadiene, D2O / acetonitrile / Irradiation; different traping reagents; other solvents; presence O2
View Scheme
参考文献
Barvian; Greenberg
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 1916 - 1917
反应条件
oxygen in water-d2; acetonitrile
Title compound not separated from byproducts;
参考文献
Barvian; Greenberg
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 1916 - 1917
反应条件
in tetrahydrofuran; water-d2
Irradiationother reagents; also aerobic conditions and thermolysis; Product distribution;
参考文献
Tallman, Keri A.; Tronche, Christopher; Yoo, Dong Jin; Greenberg, Marc M.
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 4903 - 4909
反应条件
cyclohexa-1,4-diene in water-d2; acetonitrile
Irradiation; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Barvian; Greenberg
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 1916 - 1917
反应条件
water; potassium bromide
0.333333 h; IrradiationG values of products; Product distributionMechanismRate constant;
参考文献
Cadet, J.; Voituriez, L.; Berger, M.; Myers, L. S., (Jr.)
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983 , vol. 38, # 12 p. 1643 - 1651
