4-羟基-2,3-二甲基苯甲酸甲酯合成路线 （共 20 条）
反应条件
1: aq. NaOH 2: aq. NaOH View Scheme
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=760 Torr; 19 h;
参考文献
Schultz, Arthur G.; Hardinger, Steven A.
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1105 - 1111
反应条件
sulfuric acid
Heating;
参考文献
Harris, Georgianna S.; Ellsworth, Kenneth; Witzel, Bruce E.; Tolman, Richard L.
Bioorganic Chemistry, 1996 , vol. 24, # 4 p. 386 - 400
反应条件
1: 76 percent / K2CO3 / CH2Cl2; H2O / 22 h
2: 39 percent / NaBH4, COCl2*6H2O / methanol / 0.33 h
3: 30 percent / H2 / 5percent Pd-C / ethanol / 19 h / 760 Torr
View Scheme
参考文献
Schultz, Arthur G.; Hardinger, Steven A.
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1105 - 1111
反应条件
1: 77 percent / benzene / 21 h / Irradiation
2: 76 percent / K2CO3 / CH2Cl2; H2O / 22 h
3: 39 percent / NaBH4, COCl2*6H2O / methanol / 0.33 h
4: 30 percent / H2 / 5percent Pd-C / ethanol / 19 h / 760 Torr
View Scheme
参考文献
Schultz, Arthur G.; Hardinger, Steven A.
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1105 - 1111
反应条件
1: 39 percent / NaBH4, COCl2*6H2O / methanol / 0.33 h
2: 30 percent / H2 / 5percent Pd-C / ethanol / 19 h / 760 Torr
View Scheme
参考文献
Schultz, Arthur G.; Hardinger, Steven A.
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1105 - 1111
反应条件
T=120°C; Diels-Alder reaction; 4 h;
参考文献
Barbero, Asuncion; Pulido, Francisco J.
Synthesis, 2004 , # 3 p. 401 - 404
反应条件
sulfuric acid
13 h; Inert atmosphereReflux;
参考文献
Fujii, Seiko; Chang, Stephanie Y.; Burke, Martin D.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 34 p. 7862 - 7864
反应条件
1: 2.2 g / CrO3, HOAc / H2O / Ambient temperature
2: 1.15 g / BBr3 / CH2Cl2 / -70 - 20 °C
3: 1.1 g / conc. H2SO4 / Heating
View Scheme
参考文献
Harris, Georgianna S.; Ellsworth, Kenneth; Witzel, Bruce E.; Tolman, Richard L.
Bioorganic Chemistry, 1996 , vol. 24, # 4 p. 386 - 400
反应条件
1: 1.15 g / BBr3 / CH2Cl2 / -70 - 20 °C
2: 1.1 g / conc. H2SO4 / Heating
View Scheme
参考文献
Harris, Georgianna S.; Ellsworth, Kenneth; Witzel, Bruce E.; Tolman, Richard L.
Bioorganic Chemistry, 1996 , vol. 24, # 4 p. 386 - 400
