[(S)-C10H14ClNPd]2; Ag-(S)-TRIP in chloroform T=20 - 35°C; Overman rearrangement; Inert atmosphereDarkness; optical yield given as percent eeenantioselective reaction;

1: 78 percent / sodium hydride / tetrahydrofuran / 18 h / 20 °C 2: chiral palladim(II)-based complex / CH2Cl2 / 60 h / 23 °C View Scheme

1: 88 percent / sodium hydride / tetrahydrofuran / 18 h / 20 °C 2: chiral palladim(II)-based complex; diisopropylethylamine / CH2Cl2 / 30 h / 20 °C View Scheme

1: 90 percent / PPh3; Et3N; CCl4 / Heating 2: 88 percent / NaH / tetrahydrofuran / 0 - 20 °C 3: chiral ferrocenyloxazoline palladacycle catalyst; AgOCOCF3; 1,8-bis(dimethylamino)naphthalene / CH2Cl2 / 24 h / 20 °C View Scheme

bis-μ-chloro-{(Rp)-2-[(4S,5S)-1,5-dimethyl-4-phenyl-4,5-dihydro-1H-imidazolyl]pentaphenylferrocenyl}dipalladium; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine; silver nitrate in dichloromethane T=40°C; Aza-Claisen rearrangement; 20 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;