反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 23 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 23 °C / Inert atmosphere
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: -78 - 23 °C / Inert atmosphere
4.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide / tetrahydrofuran / 3 h / 23 °C / Inert atmosphere
5.1: 4-(N,N-dimethlyamino)pyridine; 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 48 h / 23 °C / Inert atmosphere
6.1: sodium tetrahydroborate / methanol / 30 h / 0 °C / Inert atmosphere
7.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / -10 - 0 °C / Inert atmosphere
7.2: 12 h / 23 °C / Inert atmosphere
8.1: 18-crown-6 ether / toluene / 36 h / Inert atmosphere; Reflux
View Scheme
参考文献
Li, Zhenwu; Nakashige, Mika; Chain, William J.
Journal of the American Chemical Society, 2011 , vol. 133, # 17 p. 6553 - 6556