6-羟基-2,5,7,8-四甲基色满-2-羧酸合成路线 （共 8 条）
反应条件
Yield given. Multistep reaction;
参考文献
Netscher, Thomas; Gautschi, Iwan
Liebigs Annalen der Chemie, 1992 , # 6 p. 543 - 546
反应条件
potassium hydroxide in water Irradiation; Equilibrium constant;
参考文献
Steenken, S.; Neta, P.
Journal of Physical Chemistry, 1982 , vol. 86, p. 3661 - 3667
反应条件
1: imidazole / dimethylformamide 2: LAH / 3 h / 20 °C 3: potassium tert-butoxide / dimethylformamide / 8 h / 80 °C 4: AcOH; piperidine / toluene / 4 h / Heating 5: HCl / methanol / 0.25 h 6: 84 percent / CoCl2; DMG; NaBH4 / NaOH / tetrahydrofuran; H2O / 20 °C View Scheme
参考文献
Salamone, Stephane; Colin, Christelle; Grillier-Vuissoz, Isabelle; Kuntz, Sandra; Mazerbourg, Sabine; Flament, Stephane; Martin, Helne; Richert, Lysiane; Chapleur, Yves; Boisbrun, Michel
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 206 - 215
反应条件
1: With sodium hydroxide in water 2: With hydrogenchloride in water T=50°C;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP2351729 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With sodium hydroxide in water 2: With hydrogenchloride in water T=50°C;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP2351729 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
potassium hydroxide in water Irradiation; Equilibrium constant;
参考文献
Steenken, S.; Neta, P.
Journal of Physical Chemistry, 1982 , vol. 86, p. 3661 - 3667
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=4°C; Reflux;
参考文献
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
Patent: WO2009/105621 A1, 2009 ;
Location in patent: Page/Page column 38 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Suarna, Cacang; Dean, Roger T.; Southwell-Keely, Peter T.
Australian Journal of Chemistry, 1997 , vol. 50, # 12 p. 1129 - 1135
