2-甲基苯并二氢吡喃-4-酮合成路线 （共 20 条）
反应条件
1: 70 percent / dibenzo-18-crown-6
2: 70 percent / Rh2(OAc)4 / acetonitrile / 2 h / Heating
View Scheme
参考文献
Spyroudis, Spyros; Tarantili, Petroula
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4885 - 4889
反应条件
1: 1.) NaOH / H2O / Heating
2: CH3SO3H, P2O5 / 0.25 h / Heating
View Scheme
参考文献
Lipinski, Christopher A.; Aldinger, Charles E.; Beyer, Thomas A.; Bordner, Jon; Burdi, Douglas F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2169 - 2177
反应条件
1: tetrahydrofuran / 0 °C
2: sodium chloride, water / dimethylsulfoxide / 5 h / 155 - 165 °C
View Scheme
参考文献
Saengchantara, Suthiweth T.; Wallace, Timothy W.
Tetrahedron, 1990 , vol. 46, # 8 p. 3029 - 3036
反应条件
aluminium trichloride
T=140°C; Erwaermen des Reaktionsgemisches mit wss.-aethanol. Salzsaeure;
参考文献
Cavill et al.
Journal of the Chemical Society, 1954 , p. 4573,4580
反应条件
methanesulfonic acid; phosphorus pentoxide
0.25 h; Heating;
参考文献
Lipinski, Christopher A.; Aldinger, Charles E.; Beyer, Thomas A.; Bordner, Jon; Burdi, Douglas F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2169 - 2177
反应条件
in acetonitrile
Heating; Yield given;
参考文献
Spyroudis, Spyros; Tarantili, Petroula
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4885 - 4889
反应条件
PPA; Polyphosphoric acid (PPA)
1.) 120 deg C, 3 h, 2.) 140 deg C, 5 h; Multistep reaction;
参考文献
Lipinski, Christopher A.; Aldinger, Charles E.; Beyer, Thomas A.; Bordner, Jon; Burdi, Douglas F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2169 - 2177
反应条件
1: 3percent HCl / 24 h / Ambient temperature
2: 2.) sodium chloride / 1.) THF, Et2O, -10 deg C - -5 deg C, 0.5 h, 2.) DMSO/H2O, 155 deg C, 4 h
View Scheme
参考文献
Wallace, Timothy W.
Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4299 - 4302
反应条件
Yield given. Multistep reaction;
参考文献
Bergdahl, Mikael; Eriksson, Magnus; Nilsson, Martin; Olsson, Thomas
Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 7238 - 7244
反应条件
sulfuric acid; iodine; dimethyl sulfoxide
T=100°C; 1 h; or without H2SO4;
参考文献
Kapoor; Singh; Garg
Journal of the Indian Chemical Society, 1991 , vol. 68, # 6 p. 367 - 368
