2,3-二氯四氢-2H-吡喃合成路线 （共 44 条）
反应条件
1: (i) Mg, Et2O, (ii) Na 2: H2 / Raney-Ni 3: aq. HBr, H2SO4 4: ethanol 5: H2 / Raney-Ni View Scheme
参考文献
Collins,R.F.; Davis,M.
Journal of the Chemical Society, 1961 , p. 1863 - 1879
反应条件
1: 101 g / diethyl ether; tetrahydrofuran / 4 h / -5 °C 2: Na / diethyl ether / 1.5 h / Heating 3: pyridinium chlorochromate / CH2Cl2 / 1.25 h / Heating 4: 3-(2-ethoxyethyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / triethylamine; dioxane / 15 h / 87 °C 5: 1.) NaOH, 2.) NaBH4 / 1.) EtOH-H2O, reflux, 0.5 h, 2.) 2 h 6: 0.5 g / 110 deg C; -> 145 deg C, 20 min; 145 deg C, 10 min 7: H2 / 10percent Pd/C / hexane / 1 h / 16 °C View Scheme
参考文献
Synthetic Communications, , vol. 14, # 1 p. 53 - 64
反应条件
1: (i) Mg, Et2O, (ii) Na 2: H2 / Raney-Ni View Scheme
参考文献
Collins,R.F.; Davis,M.
Journal of the Chemical Society, 1961 , p. 1863 - 1879
反应条件
1: (i) Mg, Et2O, (ii) Na 2: Raney-Ni View Scheme
参考文献
Collins,R.F.; Davis,M.
Journal of the Chemical Society, 1961 , p. 1863 - 1879
反应条件
1: (i) Mg, Et2O, (ii) Na 2: H2 / Raney-Ni 3: aq. HBr, H2SO4 View Scheme
参考文献
Mamalis,P. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 684 - 691
反应条件
magnesium ether; Yield given. Multistep reaction;
参考文献
Crombie, Leslie; Wyvill, Robert D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1971 - 1982
参考文献
Riobe
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 628
Full Text Show Details
Crombie; Harper
Journal of the Chemical Society, 1950 , p. 1707,1712
反应条件
1: lithium alanate; diethyl ether 2: sodium amide; liquid ammonia View Scheme
参考文献
Crombie et al.
Journal of the Chemical Society, 1956 , p. 136,141
参考文献
Riobe
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 628
参考文献
Riobe
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 628
