2,3-二氯四氢-2H-吡喃合成路线 （共 44 条）
反应条件
1: (i) Mg, Et2O, (ii) Na 2: H2 / Raney-Ni View Scheme
参考文献
Collins,R.F.; Davis,M.
Journal of the Chemical Society, 1961 , p. 1863 - 1879
参考文献
Mamalis,P. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 684 - 691
反应条件
2: potassium hydroxide / ethanol / 12 h / Heating
3: potassium hydroxide / benzene / 12 h / Heating
4: 74 percent / lithium aluminum hydride / diethyl ether / 1 h
View Scheme
参考文献
Bouchu, D.; Dreux, J.
Phosphorus and Sulfur and the Related Elements, 1982 , vol. 13, p. 25 - 34
参考文献
Paul
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1944 , vol. 218, p. 122
参考文献
Quennehen; Normant
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1949 , vol. 228, p. 1301
反应条件
T=21.2°C; Rate constant;
参考文献
Newth; Phillips
Journal of the Chemical Society, 1953 , p. 2900,2903
反应条件
1: 1) Mg / 2) 1 h, heating; 3) 12 h
2: 63 percent / Na / diethyl ether / 12 h
3: 75 percent / pyridinium chlorochromate / CH2Cl2 / 2 h
View Scheme
参考文献
Bestmann; Koschatzky; Schaetzke; et al.
1981 , vol. No. 9, p. 1705 - 1720
反应条件
1: 101 g / diethyl ether; tetrahydrofuran / 4 h / -5 °C
2: Na / diethyl ether / 1.5 h / Heating
View Scheme
参考文献
Bestmann; Koschatzky; Vostrowsky
1982 , vol. No. 8, p. 1478 - 1494
反应条件
2: potassium hydroxide / ethanol / 12 h / Heating
3: potassium hydroxide / benzene / 12 h / Heating
View Scheme
参考文献
Bouchu, D.; Dreux, J.
Phosphorus and Sulfur and the Related Elements, 1982 , vol. 13, p. 25 - 34
反应条件
1: 101 g / diethyl ether; tetrahydrofuran / 4 h / -5 °C
2: Na / diethyl ether / 1.5 h / Heating
3: pyridinium chlorochromate / CH2Cl2 / 1.25 h / Heating
4: 3-(2-ethoxyethyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / triethylamine; dioxane / 15 h / 87 °C
View Scheme
参考文献
Voaden, Denys J.
Synthetic Communications, 1984 , vol. 14, # 1 p. 53 - 64
