5-叔丁基呋喃-2-羧酸合成路线 （共 14 条）
反应条件
1: 5-tert-butylfuran-2-carboxylic acid With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With 4-toluenesulfonyl azide in tetrahydrofuran; hexane
T=-78 - 0°C; 2 h;
3: diazomethyl-trimethyl-silane With potassium acetate
more than 3 stages;
参考文献
Bayer Pharmaceuticals Corporation; ONYX PHARMACEUTICALS, INC.
Patent: EP986382 B1, 2008 ;
Location in patent: Page/Page column 13; 22-23 ;
EP 0986382 B1
参考文献
Bayer Corporation
Patent: US6344476 B1, 2002 ;
US 6344476 B1
参考文献
Lilly Industries Limited
Patent: US4082771 A1, 1978 ;
反应条件
sulfuric acid
12 h; Heating;
参考文献
Guillard; Lamazzi; Meth-Cohn; Rees; White; Williams
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 11 p. 1304 - 1313
