2-(3,5-二羟基苯基)-6-羟基苯并呋喃合成路线 （共 23 条）
反应条件
1: With boron tribromide in dichloromethane
T=0 - 20°C; 16 h; Inert atmosphere;
2: With methanol in dichloromethane
T=0°C;
参考文献
Ikerchem, S.L.; Universidad del Pais Vasco
Patent: EP2388255 A1, 2011 ;
Location in patent: Page/Page column 20-21 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
48 h; Ambient temperature;
参考文献
Mann, Inderjit S.; Widdowson, David A.; Clough, John M.
Tetrahedron, 1991 , vol. 47, # 37 p. 7981 - 7990
反应条件
boron tribromide in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Arias, Leire; Vara, Yosu; Cossio, Fernando P.
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 266 - 275
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Kinoshita, Takeshi; Ichinose, Koji
Heterocycles, 2005 , vol. 65, # 7 p. 1641 - 1654
反应条件
1: LAH; AlCl3 / diethyl ether; tetrahydrofuran / 1.5 h
2: 11 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 7.5 h / Heating
3: hydrogen / Pd-C / ethanol
View Scheme
参考文献
Kinoshita, Takeshi; Ichinose, Koji
Heterocycles, 2005 , vol. 65, # 7 p. 1641 - 1654
反应条件
1: 11 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 7.5 h / Heating
2: hydrogen / Pd-C / ethanol
View Scheme
参考文献
Kinoshita, Takeshi; Ichinose, Koji
Heterocycles, 2005 , vol. 65, # 7 p. 1641 - 1654
反应条件
1: KOAc / acetic anhydride / 10 h / 150 °C
2: K2CO3 / acetone
3: LAH; AlCl3 / diethyl ether; tetrahydrofuran / 1.5 h
4: 11 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 7.5 h / Heating
5: hydrogen / Pd-C / ethanol
View Scheme
参考文献
Kinoshita, Takeshi; Ichinose, Koji
Heterocycles, 2005 , vol. 65, # 7 p. 1641 - 1654
反应条件
1: KOAc / acetic anhydride / 10 h / 150 °C
2: K2CO3 / acetone
3: LAH; AlCl3 / diethyl ether; tetrahydrofuran / 1.5 h
4: 11 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 7.5 h / Heating
5: hydrogen / Pd-C / ethanol
View Scheme
参考文献
Kinoshita, Takeshi; Ichinose, Koji
Heterocycles, 2005 , vol. 65, # 7 p. 1641 - 1654
反应条件
1: 90 percent / imidazole / dimethylformamide / 16 h / 50 °C
2: 1) BuLi, Me3SnCl, 2) Pd(PPh3)4 / 1) THF, rt, 1 h, 2) THF, reflux
3: 86 percent / Bu4NF / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Mann, Inderjit S.; Widdowson, David A.; Clough, John M.
Tetrahedron, 1991 , vol. 47, # 37 p. 7981 - 7990
反应条件
in acetonitrile-D3
T=80°C; 8 h;
参考文献
Celaje, Jeff A.; Zhang, Dong; Guerrero, Angela M.; Selke, Matthias
Organic Letters, 2011 , vol. 13, # 18 p. 4846 - 4849
