2-(3,5-二羟基苯基)-6-羟基苯并呋喃合成路线 （共 23 条）
反应条件
boron tribromide in dichloromethane
480 h; Ambient temperature;
参考文献
Watanabe; Kawanishi; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 579 - 583
反应条件
1: 60 percent / NaH, ethanethiol / dimethylformamide / 4 h / Heating
2: 90 percent / imidazole / dimethylformamide / 16 h / 50 °C
3: 1) BuLi, Me3SnCl, 2) Pd(PPh3)4 / 1) THF, rt, 1 h, 2) THF, reflux
4: 86 percent / Bu4NF / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Mann, Inderjit S.; Widdowson, David A.; Clough, John M.
Tetrahedron, 1991 , vol. 47, # 37 p. 7981 - 7990
反应条件
1: 1) BuLi, Me3SnCl, 2) Pd(PPh3)4 / 1) THF, rt, 1 h, 2) THF, reflux
2: 86 percent / Bu4NF / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Mann, Inderjit S.; Widdowson, David A.; Clough, John M.
Tetrahedron, 1991 , vol. 47, # 37 p. 7981 - 7990
反应条件
1: 1) sec-BuLi, N,N,N',N'-tetramethylethylenediamine / 1) cyclohexane, THF, -105 deg C, 20 min 2) THF, -105 deg C, 1h
2: 52 percent / 90percent HCO2H / 1 h / Heating
3: 18 percent / BBr3 / CH2Cl2 / 480 h / Ambient temperature
View Scheme
参考文献
Watanabe; Kawanishi; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 579 - 583
反应条件
2: 86 percent / TBAF / tetrahydrofuran / 48 h / Ambient temperature
View Scheme
参考文献
Clough, John M.; Mann, Inderjit S.; Widdowson, David A.
Tetrahedron Letters, 1987 , vol. 28, # 23 p. 2645 - 2648
反应条件
1: 82 percent / imidazole / dimethylformamide / 24 h / Ambient temperature
2: 1) sec-BuLi, N,N,N',N'-tetramethylethylenediamine / 1) cyclohexane, THF, -105 deg C, 20 min 2) THF, -105 deg C, 1h
3: 12.3 percent / 90percent HCO2H / 1 h / Heating
View Scheme
参考文献
Watanabe; Kawanishi; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 579 - 583
反应条件
1: 1) sec-BuLi, N,N,N',N'-tetramethylethylenediamine / 1) cyclohexane, THF, -105 deg C, 20 min 2) THF, -105 deg C, 1h
2: 52 percent / 90percent HCO2H / 1 h / Heating
3: 18 percent / BBr3 / CH2Cl2 / 480 h / Ambient temperature
View Scheme
参考文献
Watanabe; Kawanishi; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 579 - 583
反应条件
1: 52 percent / 90percent HCO2H / 1 h / Heating
2: 18 percent / BBr3 / CH2Cl2 / 480 h / Ambient temperature
View Scheme
参考文献
Watanabe; Kawanishi; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 579 - 583
反应条件
1: aluminum oxide / anhydrous xylene / 16 h / Reflux
2: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Arias, Leire; Vara, Yosu; Cossio, Fernando P.
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 266 - 275
反应条件
formic acid
1 h; Heating;
参考文献
Watanabe; Kawanishi; Furukawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 579 - 583
