3,5-二甲基异噁唑-4-羧酸甲酯合成路线 （共 5 条）
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19626 A1, 2013 ;
WO 2013/019626 A1
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 2: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C 3: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 4: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19626 A1, 2013 ;
Location in patent: Page/Page column 26 ;
WO 2013/019626 A1
反应条件
thionyl chloride
T=70°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19626 A1, 2013 ;
Location in patent: Page/Page column 25; 26 ;
WO 2013/019626 A1
反应条件
triethylamine in benzene
T=70°C; 2 h; Microwave irradiation; regioselective reaction;
参考文献
Lasri, Jamal; Mukhopadhyay, Suman; Charmier, M. Adilia Januario
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1385 - 1389
