4,5-二溴-2-苯基-1H-咪唑合成路线 （共 3 条）
反应条件
N-bromosuccinmide in tetrahydrofuran
T=0 - 20°C; 1 h;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; O'CONNOR, Patrick; RIPKA, William; MATTHEWS, David; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85269 A1, 2011 ;
Location in patent: Page/Page column 75 ;
WO 2011/085269 A1
参考文献
Forsyth; Nimkar; Pyman
Journal of the Chemical Society, 1926 , p. 802
反应条件
1: 51 percent / Na2SO3 / aq. ethanol / 46 h / Heating
2: 57 percent / NaH / tetrahydrofuran / 1.) 0 deg C -> RT, 30 min, 2.) 0 deg C -> RT, 12 h
View Scheme
参考文献
Breslow, Ronald; Hunt, John T.; Smiley, Richard; Tarnowski, Thomas
Journal of the American Chemical Society, 1983 , vol. 105, # 16 p. 5337 - 5342
