4-(4-氟苯甲酰基)哌啶合成路线 （共 20 条）
反应条件
sodium carbonate in butanone 24 h; Reflux;
参考文献
Fakhraian, Hossein; Heydary, Mehdi
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156
反应条件
in neat (no solvent) T=110°C;
参考文献
Fakhraian, Hossein; Heydary, Mehdi
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156
参考文献
Janssen Pharmaceutica N.V.
Patent: US4035369 A1, 1977 ;
反应条件
triethylamine in tetrahydrofuran Ambient temperature;
参考文献
Bolos, Jordi; Gubert, Santiago; Anglada, Lluis; Planas, Josep M.; Burgarolas, Carme; Castello, Josep M.; Sacristan, Aurelio; Ortiz, Jose A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2962 - 2970
反应条件
potassium carbonate in 1,4-dioxane Heating;
参考文献
Herndon, Jeff L.; Ismaiel, Abd; Ingher, Stacy P.; Teitler, M.; Glennon, Richard A.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4903 - 4910
反应条件
potassium carbonate; potassium iodide in various solvent(s)
22 h; Heating;
参考文献
Fu, Xing; Tan, Ping-Zhong; Kula, Nora S.; Baldessarini, Ross; Tamagnan, Gilles; Innis, Robert B.; Baldwin, Ronald M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2319 - 2324
反应条件
in methanol; dichloromethane
参考文献
Adir et Compagnie
Patent: US5077288 A1, 1991 ;
反应条件
1: 86 percent / NaOH / ethanol / 2 h / Heating
2: 77 percent / CCl4; Ph3P / pyridine / 1 h / 20 °C
View Scheme
参考文献
Claudi; Giorgioni; Scoccia; Ciccocioppo; Panocka; Massi
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 651 - 659
反应条件
in acetone
T=30°C; 12 h;
参考文献
Tripathi; Singh; Saxena
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 9 p. 865 - 869
反应条件
hydrogenchloride; potassium iodide; sodium carbonate in acetone
参考文献
Janssen Pharmaceutica N.V.
Patent: US4035369 A1, 1977 ;
