3,4-二苯基-5H-呋喃-2-酮合成路线 （共 40 条）
反应条件
1: 89 percent / N,N'-dibromodimethylhydantoin / CCl4 / 12 h / 50 - 60 °C
2: 80 percent / AgClO4 / tetrahydrofuran; H2O / 0.17 h / Ambient temperature
3: 92 percent / HCl / CHCl3 / 1 h / Ambient temperature
View Scheme
参考文献
Toda, Fumio; Takehira, Yoshikazu; Kataoka, Yutaka; Mori, Koji; Sato, Tamie; Segawa, Mari
Journal of the Chemical Society, Chemical Communications, 1984 , # 18 p. 1234 - 1235
反应条件
1: 87 percent / TiCl4, Zn / tetrahydrofuran / 24 h / 50 - 60 °C
2: 89 percent / N,N'-dibromodimethylhydantoin / CCl4 / 12 h / 50 - 60 °C
3: 80 percent / AgClO4 / tetrahydrofuran; H2O / 0.17 h / Ambient temperature
4: 92 percent / HCl / CHCl3 / 1 h / Ambient temperature
View Scheme
参考文献
Toda, Fumio; Takehira, Yoshikazu; Kataoka, Yutaka; Mori, Koji; Sato, Tamie; Segawa, Mari
Journal of the Chemical Society, Chemical Communications, 1984 , # 18 p. 1234 - 1235
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 - 0 °C
1.2: 3 h / -78 - 20 °C
2.1: iodine / toluene / 2 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / benzene / 0.5 h / 100 °C / |Microwave irradiation
View Scheme
参考文献
Reddy, Maddi Sridhar; Thirupathi, Nuligonda; Hari Babu, Madala; Puri, Surendra
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 5878 - 5888
反应条件
1: iodine / toluene / 2 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / benzene / 0.5 h / 100 °C / |Microwave irradiation
View Scheme
参考文献
Reddy, Maddi Sridhar; Thirupathi, Nuligonda; Hari Babu, Madala; Puri, Surendra
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 5878 - 5888
反应条件
1: triethylamine / acetonitrile / 1 h / 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.25 h / 0 °C
View Scheme
参考文献
Yamakawa, Naoki; Suzuki, Koichiro; Yamashita, Yasunobu; Katsu, Takashi; Hanaya, Kengo; Shoji, Mitsuru; Sugai, Takeshi; Mizushima, Tohru
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2529 - 2534
反应条件
1: tetrahydrofuran; cyclohexane / 19 h / 80 °C / Heating
View Scheme
参考文献
Forgione, Pat; Wilson, Peter D.; Fallis, Alex G.
Tetrahedron Letters, 2000 , vol. 41, # 1 p. 17 - 20
反应条件
1: tetrahydrofuran; cyclohexane / 19 h / 80 °C / Heating
View Scheme
参考文献
Forgione, Pat; Wilson, Peter D.; Fallis, Alex G.
Tetrahedron Letters, 2000 , vol. 41, # 1 p. 17 - 20
反应条件
oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=10 - 15°C; 6 h; Product distribution; Further Variations:TemperaturesReagents;
参考文献
Pattabiraman, Vijaya Raghavan; Padakanti, Srinivas; Veeramaneni, Venugopal Rao; Pal, Manojit; Yeleswarapu, Koteswar Rao
Synlett, 2002 , # 6 p. 947 - 951
参考文献
Forgione, Pat; Wilson, Peter D.; Fallis, Alex G.
Tetrahedron Letters, 2000 , vol. 41, # 1 p. 17 - 20
反应条件
lithium aluminium tetrahydride in diethyl ether
1a.) -20 deg C, 0.5 h, b.) from -20 deg C to RT, 1 h;
参考文献
Urove, Greg A.; Welker, Mark E.; Eaton, Bruce E.
Journal of Organometallic Chemistry, 1990 , vol. 384, p. 105 - 114
