3,3,3-三氟-2-甲基丙酸乙酯合成路线 （共 6 条）
反应条件
potassium fluoride in dimethyl sulfoxide
T=170°C; 2 h;
参考文献
Purrington, Suzanne, T.; Everett, T. Stephen; Bumgardner, Carl L.
Tetrahedron Letters, 1984 , vol. 25, # 13 p. 1329 - 1332
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Everett, Stephen T.; Purrington, Suzanne T.; Bumgardner, Carl L.
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3702 - 3706
反应条件
1: 1) NaH / 1) RT, 0.5h, 2) RT
2: 44 percent / KF / dimethylsulfoxide / 2 h / 170 °C
View Scheme
参考文献
Everett, Stephen T.; Purrington, Suzanne T.; Bumgardner, Carl L.
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3702 - 3706
反应条件
bis-triphenylphosphine-palladium(II) chloride in acetonitrile
T=100°C; P=83600.1 Torr; 62 h; var. catalysts, var. times, var. solvents, other temp.: 120 degC; other reaction partners: MeOH, i-PrOH; Product distributionMechanism;
参考文献
Fuchikami, Takamasa; Ohishi, Katsuyuki; Ojima, Iwao
Journal of Organic Chemistry, 1983 , vol. 48, # 21 p. 3803 - 3807
反应条件
potassium hydroxide in methanol
(electrochemical oxidation);
参考文献
Renaud,R.N.; Champagne,P.J.
Canadian Journal of Chemistry, 1975 , vol. 53, p. 529 - 534
反应条件
potassium fluoride; dibromo-difluoro-methane; sodium hydride
1) THF, reflux, 1h, 2) room temperature, 3) DMSO, 170 deg C, 2 h; a new method for preparation of α-trifluoromethyl esters via modified malonate synthesis;
参考文献
Purrington, Suzanne, T.; Everett, T. Stephen; Bumgardner, Carl L.
Tetrahedron Letters, 1984 , vol. 25, # 13 p. 1329 - 1332
反应条件
hydrogenchloride in 1,4-dioxane
15 h; Heating;
参考文献
Beier, Petr; Z. Slawin, Alexandra M.; O'Hagan, David
Tetrahedron Asymmetry, 2004 , vol. 15, # 16 p. 2447 - 2449
