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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
N-(4-氰基苯基)胍
合成路线
（共 5 条）
420-04-2
单氰胺
+
873-74-5
对氨基苯腈
→
反应条件
5637-42-3
N-(4-氰基苯基)胍
反应条件
1: With nitric acid in ethanol 6 h; Reflux; 2: With water; sodium hydroxide 0.0833333 h; Reflux;
参考文献
Courme, Caroline; Gresh, Nohad; Vidal, Michel; Lenoir, Christine; Garbay, Christiane; Florent, Jean-Claude; Bertounesque, Emmanuel
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 244 - 255
5637-42-3
N-(4-氰基苯基)胍
+
105-53-3
丙二酸二乙酯
→
反应条件
374067-80-8
4-(4-羟基-6-氧代-1,6-二氢嘧啶-2-基氨基)苯甲腈
反应条件
ethanol; sodium 12 h; Reflux;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; VAMSI KRISHNA, Bandi; VENKAT NARSIMHA REDDY, Adulla
Patent: WO2012/1695 A1, 2012 ;
Location in patent: Page/Page column 11 ;
5637-42-3
N-(4-氰基苯基)胍
→
反应条件
329187-59-9
4-N[2(4,6-二氯吡啶基)]-氨基苯腈
反应条件
1: ethanol; sodium / 12 h / Reflux 2: trichlorophosphate; N,N-dimethyl-aniline / 6 h / Reflux View Scheme
参考文献
HETERO RESEARCH FOUNDATION; Parthasaradhi Reddy, Bandi; Rathnakar Reddy, Kura; Muralidhara Reddy, Dasari; Raji Reddy, Rapolu; Vamsi Krishna, Bandi; Venkat Narsimha Reddy, Adulla
Patent: US2013/96148 A1, 2013 ;
5637-42-3
N-(4-氰基苯基)胍
→
反应条件
1398507-08-8
反应条件
1.1: potassium tert-butylate / butan-1-ol / 4 h / 60 - 93 °C 2.1: trichlorophosphate / 20 - 85 °C 2.2: pH 9 - 10 View Scheme
参考文献
Gore, Vinayak; Bharati, Choudhari; Hublikar, Mahesh; Bansode, Prakash; Sinore, Sandip
Patent: US2013/116433 A1, 2013 ;
5637-42-3
N-(4-氰基苯基)胍
→
反应条件
269055-15-4
依曲韦林
反应条件
1.1: ethanol; sodium / 12 h / Reflux 2.1: trichlorophosphate; N,N-dimethyl-aniline / 6 h / Reflux 3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 12 h / 45 °C 4.1: ammonia / 1,4-dioxane; water / 12 h / 120 °C 5.1: bromine / dichloromethane / 4 h / 0 - 5 °C 5.2: pH 9 - 10 View Scheme
参考文献
HETERO RESEARCH FOUNDATION; Parthasaradhi Reddy, Bandi; Rathnakar Reddy, Kura; Muralidhara Reddy, Dasari; Raji Reddy, Rapolu; Vamsi Krishna, Bandi; Venkat Narsimha Reddy, Adulla
Patent: US2013/96148 A1, 2013 ;
