甲基2-氨基-1,3-苯并恶唑-5-羧酸酯合成路线 （共 5 条）
反应条件
bromine cyanide in methanol; water
T=20°C; 0.833333 h; Cooling with ice;
参考文献
Rajyalakshmi; Reddy, A. Rama Narsimha; Sarangapani
Letters in Drug Design and Discovery, 2012 , vol. 9, # 6 p. 625 - 632
反应条件
in tetrahydrofuran
T=70°C; 4 h;
参考文献
Yamazaki, Kazuo; Kaneko, Yasushi; Suwa, Kie; Ebara, Shinji; Nakazawa, Kyoko; Yasuno, Kazuhiro
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2509 - 2522
反应条件
1: sodium dithionite / ethanol; water / Heating
2: bromine cyanide / methanol; water / 0.83 h / 20 °C / Cooling with ice
View Scheme
参考文献
Rajyalakshmi; Reddy, A. Rama Narsimha; Sarangapani
Letters in Drug Design and Discovery, 2012 , vol. 9, # 6 p. 625 - 632
反应条件
1: aluminium trinitrate; acetic anhydride / acetic acid / 1.5 h / 20 °C
2: sodium dithionite / ethanol; water / Heating
3: bromine cyanide / methanol; water / 0.83 h / 20 °C / Cooling with ice
View Scheme
参考文献
Rajyalakshmi; Reddy, A. Rama Narsimha; Sarangapani
Letters in Drug Design and Discovery, 2012 , vol. 9, # 6 p. 625 - 632
反应条件
(i) H2, Raney-Ni, (ii) /BRN= 1697296/; Multistep reaction;
参考文献
Schuart; Mueller
Pharmazie, 1975 , vol. 30, # 3 p. 155 - 157
