sodium tetrahydroborate in methanol 90 h;

1: 85 percent / methanol / 0.5 h / Heating 2: 80 percent / NaOH / dimethylformamide / 2 h / Heating 3: 67 percent / aq. HCl / acetone / 2 h / Heating 4: 1.) TsCl, 2.) NaH / 1.) pyridine, 0 deg C, 4 d, 2.) reflux, 90 min 5: 40 percent / NH4Cl / 24 h 6: 95 percent / NaBH4 / methanol / 90 h View Scheme

1: 80 percent / NaOH / dimethylformamide / 2 h / Heating 2: 67 percent / aq. HCl / acetone / 2 h / Heating 3: 1.) TsCl, 2.) NaH / 1.) pyridine, 0 deg C, 4 d, 2.) reflux, 90 min 4: 40 percent / NH4Cl / 24 h 5: 95 percent / NaBH4 / methanol / 90 h View Scheme

1: 40 percent / NH4Cl / 24 h 2: 95 percent / NaBH4 / methanol / 90 h View Scheme

1: 1.) TsCl, 2.) NaH / 1.) pyridine, 0 deg C, 4 d, 2.) reflux, 90 min 2: 40 percent / NH4Cl / 24 h 3: 95 percent / NaBH4 / methanol / 90 h View Scheme

1: 67 percent / aq. HCl / acetone / 2 h / Heating 2: 1.) TsCl, 2.) NaH / 1.) pyridine, 0 deg C, 4 d, 2.) reflux, 90 min 3: 40 percent / NH4Cl / 24 h 4: 95 percent / NaBH4 / methanol / 90 h View Scheme

NADPH; recombinant human CYP2D6 in phosphate buffer T=37°C; pH=7.4; Enzyme kinetics; Further Variations:Catalysts;

CYP2D6.1; NADPH in phosphate buffer pH=7.4; Enzyme kinetics; Further Variations:Reagents;