1,8-二氮杂环十四烷-2,9-二酮合成路线 （共 17 条）
反应条件
in water; toluene T=370°C; P=111011 - 155266 Torr; 1 - 3 h; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1975156 A1, 2008 ;
Location in patent: Page/Page column 4; 5-6 ;
反应条件
T=78°C; und 100grad.Hydrolysis; Rate constant;
参考文献
Heikens et al.
Makromolekulare Chemie, 1959 , vol. 30, p. 154,167
反应条件
1: 83 percent / 4 M NaOH / 4 h / 0 - 20 °C
2: DCC / dioxane / 24 h / 0 °C
3: aq. NaHCO3 / 1,2-dimethoxy-ethane / 5 h / 20 °C
4: 90 percent / DCC / dimethylformamide / 3 h / 0 - 20 °C
5: 33percent HBr / acetic acid / 2 h / 20 °C
6: pyridine / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 94 percent / 1,2-dimethoxy-ethane / 3 h
2: 100 percent / H2, AcOH / 10percent Pd/C / methanol / 1 h / 760 Torr
3: 90 percent / DCC / ethyl acetate / 3 h / 0 - 20 °C
4: 0.25 h / 50 °C
5: Et3N / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 55 percent / DCC / 1,2-dimethoxy-ethane / 20 h / 0 °C
2: 94 percent / 1,2-dimethoxy-ethane / 3 h
3: 100 percent / H2, AcOH / 10percent Pd/C / methanol / 1 h / 760 Torr
4: 90 percent / DCC / ethyl acetate / 3 h / 0 - 20 °C
5: 0.25 h / 50 °C
6: Et3N / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
pyridine in N,N-dimethyl-formamide
T=60°C; 4 h; Yield given;
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 100 percent / H2, AcOH / 10percent Pd/C / methanol / 1 h / 760 Torr
2: 90 percent / DCC / ethyl acetate / 3 h / 0 - 20 °C
3: 0.25 h / 50 °C
4: Et3N / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 90 percent / DCC / dimethylformamide / 3 h / 0 - 20 °C
2: 33percent HBr / acetic acid / 2 h / 20 °C
3: pyridine / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
ueber 6-<6-Amino-hexanoylamino>-hexansaeure-hydrazid-hydrobromid und das entsprechende Azid;
参考文献
Zahn; Determann
Chemische Berichte, 1957 , vol. 90, p. 2176,2180
反应条件
1: DCC / dioxane / 24 h / 0 °C
2: aq. NaHCO3 / 1,2-dimethoxy-ethane / 5 h / 20 °C
3: 90 percent / DCC / dimethylformamide / 3 h / 0 - 20 °C
4: 33percent HBr / acetic acid / 2 h / 20 °C
5: pyridine / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
