1,8-二氮杂环十四烷-2,9-二酮合成路线 （共 17 条）
反应条件
1: aq. NaHCO3 / 1,2-dimethoxy-ethane / 5 h / 20 °C
2: 90 percent / DCC / dimethylformamide / 3 h / 0 - 20 °C
3: 33percent HBr / acetic acid / 2 h / 20 °C
4: pyridine / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 93 percent / 85percent N2H4*H2O / methanol / 24 h / 20 °C
2: 33percent HBr / acetic acid / 1 h / 20 °C
3: 1 M HCl, aq. NaNO2 / 0.25 h / 0 °C
4: aq. NaHCO3 / 4 h / 20 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 33percent HBr / acetic acid / 2 h / 20 °C
2: pyridine / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 90 percent / DCC / ethyl acetate / 3 h / 0 - 20 °C
2: 0.25 h / 50 °C
3: Et3N / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
反应条件
1: 0.25 h / 50 °C
2: Et3N / dimethylformamide / 4 h / 60 °C
View Scheme
参考文献
Mikhura, I. V.; Formanovskii, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 2 p. 205 - 212
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 2 p. 247 - 255
参考文献
Zahn; Rexroth
Zeitschrift fuer Analytische Chemie, 1955 , vol. 148, p. 181,186
反应条件
6-aminohexanoate cyclic dimer hydrolase Arthrobacter sp.
T=30°C; pH=7; aq. phosphate bufferEnzymatic reaction; Kinetics;
参考文献
Yasuhira, Kengo; Shibata, Naoki; Mongami, Go; Uedo, Yuki; Atsumi, Yu; Kawashima, Yasuyuki; Hibino, Atsushi; Tanaka, Yusuke; Lee, Young-Ho; Kato, Dai-Ichiro; Takeo, Masahiro; Higuchi, Yoshiki; Negoro, Seiji
Journal of Biological Chemistry, 2010 , vol. 285, # 2 p. 1239 - 1248
