1-(N-苯丙氨酰)吡咯烷合成路线 （共 4 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 18 h; 2: With sodium hydroxide in tetrahydrofuran; water
参考文献
Infinity Discovery, Inc.
Patent: US2008/114167 A1, 2008 ;
Location in patent: Page/Page column 170 ;
US 20080114167 A1
反应条件
methanol; acetyl chloride
T=0 - 20°C; 4 h;
参考文献
Ishihara, Kazuaki; Nakano, Kazuhiko
Journal of the American Chemical Society, 2005 , vol. 127, # 30 p. 10504 - 10505
反应条件
1: 99 percent / Et3N; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium*PF6 / tetrahydrofuran / 8 h / 0 - 20 °C
2: AcCl; MeOH / 4 h / 0 - 20 °C
View Scheme
参考文献
Ishihara, Kazuaki; Nakano, Kazuhiko
Journal of the American Chemical Society, 2005 , vol. 127, # 30 p. 10504 - 10505
反应条件
4-methyl-morpholine; isobutyl chloroformate
1.) CH2Cl2, 0 deg C, 30 min., 2.) 0 deg C, 30 min., r.t., 2 h; Yield given. Multistep reaction;
参考文献
Obrecht; Spiegler; Schonholzer; Muller; Heimgartner; Stierli
Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1666 - 1696
