1: ethyl acetoacetate; 1-(4-methylphenyl)hydrazine in toluene T=120°C; 17 h; Sealed tubeMolecular sieveDarkness; 2: methyl iodide in toluene; acetonitrile T=120°C; 17 h; Sealed tubeDarkness;

methanol T=100°C;

2: 130 - 140 °C 3: methanol / 100 °C View Scheme