2-[2-(4-甲氧基苯基)乙基]环氧乙烷合成路线 （共 7 条）
反应条件
sodium hydride; dimethyl sulfoxide
1.) 65 deg C, 1.5 h, 2.) THF, 0 deg C, 0.5 h; 25 deg C, 2 h;
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
参考文献
G.D. Searle and Co.
Patent: EP267439 A3, 1988 ;
反应条件
1: 97.5 percent / lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 5 h
2: 83 percent / chromium trioxide, pyridine / CH2Cl2 / 0.17 h / 25 °C
3: 86 percent / 1.) sodium hydride, Me2SO / 1.) 65 deg C, 1.5 h, 2.) THF, 0 deg C, 0.5 h; 25 deg C, 2 h
View Scheme
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
反应条件
1: 83 percent / chromium trioxide, pyridine / CH2Cl2 / 0.17 h / 25 °C
2: 86 percent / 1.) sodium hydride, Me2SO / 1.) 65 deg C, 1.5 h, 2.) THF, 0 deg C, 0.5 h; 25 deg C, 2 h
View Scheme
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
反应条件
sodium hydroxide; tetra-n-butyl-ammonium sulfate in dichloromethane
10 h; Yield given;
参考文献
Fuhrer; Ostermayer; Zimmermann; Meier; Mueller
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 831 - 836
反应条件
1: diethyl ether; benzene / 2 h / Heating
2: tetrabutylammonium sulfate, 4 N NaOH / CH2Cl2 / 10 h
View Scheme
参考文献
Fuhrer; Ostermayer; Zimmermann; Meier; Mueller
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 831 - 836
反应条件
sodium hydrogencarbonate in sulfuric acid; water
参考文献
Janssen Pharmaceutica N.V.
Patent: US3936470 A1, 1976 ;
Title/Abstract Full Text Show Details
Janssen Pharmaceutica N.V.
Patent: US4139540 A1, 1979 ;
