15-巯基-4,7,10,13-四氧杂十五烷酸叔丁酯合成路线 （共 7 条）
反应条件
acetic acid in tetrahydrofuran; ethanol
参考文献
ImmunoGen, Inc.
Patent: US2004/1838 A1, 2004 ;
反应条件
hydrogenchloride; triethyl amine hydrochloride in methanol
参考文献
ImmunoGen, Inc.
Patent: US2004/1838 A1, 2004 ;
反应条件
hydroxylamine buffer in ethanol
pH=7.5; 1.5 h;
参考文献
Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805
反应条件
1.1: Na / tetrahydrofuran
1.2: 78 percent / tetrahydrofuran / 20 h / 20 °C
2.1: 80 percent / Et3N / acetonitrile / 5 h / 20 °C
3.1: 92 percent / ethanol / 4 h / 20 °C
4.1: aq. hydroxylamine buffer / ethanol / 1.5 h / pH 7.5
View Scheme
参考文献
Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805
反应条件
1.1: Na / tetrahydrofuran
1.2: 78 percent / tetrahydrofuran / 20 h / 20 °C
2.1: 80 percent / Et3N / acetonitrile / 5 h / 20 °C
3.1: 92 percent / ethanol / 4 h / 20 °C
4.1: aq. hydroxylamine buffer / ethanol / 1.5 h / pH 7.5
View Scheme
参考文献
Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805
反应条件
1: 80 percent / Et3N / acetonitrile / 5 h / 20 °C
2: 92 percent / ethanol / 4 h / 20 °C
3: aq. hydroxylamine buffer / ethanol / 1.5 h / pH 7.5
View Scheme
参考文献
Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805
反应条件
1: 92 percent / ethanol / 4 h / 20 °C
2: aq. hydroxylamine buffer / ethanol / 1.5 h / pH 7.5
View Scheme
参考文献
Miller, Michael L.; Roller, Elizabeth E.; Zhao, Robert Y.; Leece, Barbara A.; Ab, Olga; Baloglu, Erkan; Goldmacher, Victor S.; Chari, Ravi V. J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4802 - 4805
