2-氨基-2-(4-氟苯基)乙腈合成路线 （共 9 条）
反应条件
Carbonate buffer; nitrilase 5275 pH=10.8; Title compound not separated from byproducts;
参考文献
Chaplin, Jennifer A.; Levin, Michael D.; Morgan, Brian; Farid, Nancy; Li, Jen; Zhu, Zuolin; McQuaid, Jeff; Nicholson, Lawrence W.; Rand, Cynthia A.; Burk, Mark J.
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2793 - 2796
反应条件
Carbonate buffer; nitrilase 5275 pH=10.8; Title compound not separated from byproducts;
参考文献
Chaplin, Jennifer A.; Levin, Michael D.; Morgan, Brian; Farid, Nancy; Li, Jen; Zhu, Zuolin; McQuaid, Jeff; Nicholson, Lawrence W.; Rand, Cynthia A.; Burk, Mark J.
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2793 - 2796
反应条件
Hydrolysis; Alkaline hydrolysis;
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
Carbonate buffer; nitrilase 5275 pH=10.8; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 18 p. 2793 - 2796
反应条件
ammonium chloride in water
参考文献
Sumitomo Chemical Company, Limited
Patent: US6015774 A1, 2000 ;
反应条件
ammonium hydroxide; ammonium chloride
T=0 - 20°C;
参考文献
Chaplin, Jennifer A.; Levin, Michael D.; Morgan, Brian; Farid, Nancy; Li, Jen; Zhu, Zuolin; McQuaid, Jeff; Nicholson, Lawrence W.; Rand, Cynthia A.; Burk, Mark J.
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2793 - 2796
反应条件
ammonium hydroxide
Addition; Strecker reaction;
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
参考文献
Gruppo Lepetit S.p.A.
Patent: US4140696 A1, 1979 ;
反应条件
1: p-toluenesulfonic acid / benzene / 8 h / Heating
2: sodium ethoxide / ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Tarzia; Panzone; Leali; Burdisso; Schiatti; Selva
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 6 p. 538 - 558
