5-(1,1-二甲基庚基)间苯二酚合成路线 （共 12 条）
反应条件
trimethylsilyl iodide in pyridine; chloroform T=60°C; 24 h;
参考文献
Singh, Vishwakarma; Kane, Vinayak V.; Martin, Arnold R.
Synthetic Communications, 1981 , vol. 11, # 6 p. 429 - 438
反应条件
1: diethyl ether; potassium; carbon disulfide / Erhitzen des Reaktionsprodukts unter vermindertem Druck 2: Raney nickel / Hydrogenation 3: aqueous HBr; acetic acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 70, p. 662
US2509387 , ;
反应条件
1: KOtBu / xylene 2: Py*HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 20, # 1 p. 17 - 24
反应条件
1: 1.) n-BuLi / 1.) THF-hexane, -78 deg C, 1 h, 2.) -> RT, then reflux, 3 h 2: 6.7 g / 1.) n-BuI / 1.) THF-hexane, -78 deg C, 2 h, 2.) RT, 2 h 3: 70 percent / NH2NH2, KOH / bis-(2-hydroxy-ethyl) ether / 120 deg C, 1 h; 180-190 deg C, 4 h 4: 99 percent / Me3SiI / CHCl3; pyridine / 24 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 11, # 6 p. 429 - 438
反应条件
1: 70 percent / NH2NH2, KOH / bis-(2-hydroxy-ethyl) ether / 120 deg C, 1 h; 180-190 deg C, 4 h 2: 99 percent / Me3SiI / CHCl3; pyridine / 24 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 11, # 6 p. 429 - 438
反应条件
1: boron trifluoride etherate / CH2Cl2 / -20 °C 2: 96 percent / lithium aluminum hydride View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 1, # 5 p. 315 - 318
反应条件
1: boron trifluoride etherate / CH2Cl2 / -20 °C 2: lithium aluminum hydride View Scheme
参考文献
Mechoulam, Raphael; Lander, Naftali; Breuer, Aviva; Zahalka, Jamal
Tetrahedron: Asymmetry, 1990 , vol. 1, # 5 p. 315 - 318
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=-20°C;
参考文献
Mechoulam, Raphael; Lander, Naftali; Breuer, Aviva; Zahalka, Jamal
Tetrahedron: Asymmetry, 1990 , vol. 1, # 5 p. 315 - 318
反应条件
hydrogenchloride in benzene
参考文献
Eli Lilly and Company
Patent: US4148809 A1, 1979 ;
反应条件
tin(IV) chloride in dichloromethane
参考文献
Eli Lilly and Company
Patent: US4054581 A1, 1977 ;
