甲基2-甲氧基-1-吡咯烷羧酸酯合成路线 （共 27 条）
反应条件
triethylamine
T=-78°C; 3.5 h; UV-irradiationInert atmosphere;
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
1: 1-chloro-2-oxopiperidin-3-yl acetate in dichloromethane
T=-78°C; 4 h; UV-irradiationInert atmosphere;
2: methanol With potassium carbonate
T=20°C; 18 h; Inert atmosphere;
参考文献
Winter, Dana K.; Drouin, Alexandre; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2610 - 2618
反应条件
T=20°C; Electrolysis; Title compound not separated from byproducts.;
参考文献
Horcajada, Roberto; Okajima, Masayuki; Suga, Seiji; Yoshida, Jun-Ichi
Chemical Communications, 2005 , # 10 p. 1303 - 1305
反应条件
1: phosphorus; bromine
2: triethylamine / dichloromethane / 5 h / 0 - 20 °C
3: 18-crown-6 ether / acetonitrile / 5 h / Reflux
4: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 1.5 h / 20 °C / 760.05 Torr
5: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 0 - 20 °C
6: triethylamine / 3.5 h / -78 °C / UV-irradiation; Inert atmosphere
View Scheme
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
1: 18-crown-6 ether / acetonitrile / 5 h / Reflux
2: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 1.5 h / 20 °C / 760.05 Torr
3: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 0 - 20 °C
4: triethylamine / 3.5 h / -78 °C / UV-irradiation; Inert atmosphere
View Scheme
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
1: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 1.5 h / 20 °C / 760.05 Torr
2: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 0 - 20 °C
3: triethylamine / 3.5 h / -78 °C / UV-irradiation; Inert atmosphere
View Scheme
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 0 - 20 °C
2: triethylamine / 3.5 h / -78 °C / UV-irradiation; Inert atmosphere
View Scheme
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
2: 18-crown-6 ether / acetonitrile / 5 h / Reflux
3: 5 Pd(II)/C(eggshell); hydrogen / ethanol / 1.5 h / 20 °C / 760.05 Torr
4: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 0 - 20 °C
5: triethylamine / 3.5 h / -78 °C / UV-irradiation; Inert atmosphere
View Scheme
参考文献
Drouin, Alexandre; Winter, Dana K.; Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2011 , vol. 76, # 1 p. 164 - 169
反应条件
titanium tetrachloride in dichloromethane
T=-5 - 5°C; 4.5 h; further Lewis acids (BF3*O(C2H5)2);
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Tsubata, Kenji
Journal of the American Chemical Society, 1981 , vol. 103, # 5 p. 1172 - 1176
反应条件
hydrogenchloride in methanol
3.5 h; Heating;
参考文献
Shono, Tatsuya; Matsumura, Yoshihiro; Tsubata, Kenji
Journal of the American Chemical Society, 1981 , vol. 103, # 5 p. 1172 - 1176
